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biopharmaceuticals biochemistry and biotecnology - Walsh G.

Walsh G. biopharmaceuticals biochemistry and biotecnology - John Wiley & Sons, 2003. - 572 p.
ISBN 0-470-84327-6
Download (direct link): biochemistryandbiotechnology2003.pdf
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phosphorothioate-based oligos 492-3
phylogenetic profiling 47
PI-3 kinase pathway 307
PIAS-1 203
PIAS family 202
picornaviruses 447
pipework 109
pit vipers 5, 408
pituitary dwarfism 327, 328-30
plague vaccine 437
plants
cell culture 32-3
as pharmaceutical source 4, 27-33, 52-3 transgenic 122-3 vaccines in 123 plasma 404
plasma expanders 354, 357 plasma thromboplastin antecedent 359 plasmacytoma cells 239 plasmid DNA manufacture 480-2 naked 476 plasmin 381, 383 plasminogen 381 Plasmodium spp. 352 plastic pipework 109
platelet-derived growth factor (PDGF) 278, 287-9 platelets 273, 353
aggregation inhibition 27 counts 241 pluripoietin 258 pluripoietin-a 259 pluripotential stem cells 255 PMSF 144
pneumococcal vaccine 437, 440 Podophyllum peltatum 426 ‘Points to Consider’ 96, 97 pokeweed 423 pol 468
poliomyelitis vaccine 438, 439 polyclonal antibodies 13, 403-9 polyethylene glycol (PEG) 152, 390, 478 polyglycol coupling 390 polylysine chains 477, 478 polymer vectors 477-8 polymorphonuclear leukocytes 192 polymyxins 39
polyol stabilizing agents 151, 152 polyoma 427 polyplexes 478 polysorbate 152 Porcilis AR-T DF 12, 504 Porcilis pesti 12, 124, 453, 505 Porcilis porcoli 12, 504 porcine FSH (p-FSH) 344
INDEX 547
porcine insulin 306, 309 enzymatic conversion 311-12 porcine LH (p-LH) 344 post-marketing surveillance 43, 74 post-menopausal symptoms 16 postnatal toxicity 71 potable water 105, 106 potato 122 potency 161-3 powdered format 142 poxviruses 446 PPL Therapeutics 121 pre-anaesthetic 29 pre-clinical trials 69-73 PredictProtein 512 pregnant mare serum gonadotrophin 332, 335-6, 340, 344-5 prekallikrein 360 prematurity 272 pre-menstrual tension 345 preproinsulin 306 pressure sores 279 Primavax 442, 504 Principles of Protein Structure 512 prior art 62 proaccelerin 359 procedure validation 183-4 process patent 63 validation 183-4 processing instructions 110-11 Procomvax 442, 504 proconvertin 359 Procrit 11, 270, 502 prodrugs 424-6 product
characterization 57 patent 62 products of biotechnology 1, 3 progesterone 17, 19, 20, 333 progestogens 17, 19, 20 proinsulin 306, 307 Proleukin 224, 228, 503 Prontosil rubrum 4, 6 prospective validation 184 prostaglandins 13, 23, 25-7 ProstaScint 416, 505 prostate cancer 14, 16, 345 protamine zinc insulin 310, 317, 318 Protaphane 315, 501 protease domain 383 protease inhibitors 144 proteases, wound debridement 398 protein 4 biological activity 142-50 catabolism 330
concentration determination 163-4 deamination 144-5 protein A chromatography 142 protein-based contaminants 159-60 detection 164-6 protein C 372, 379-80 Protein Databank (PDB) 512 protein kinase C 290, 338 proteolytic degradation 143-4 proteomics 49-50, 51 prothrombin 359, 361 proton-NMR 173 Protropin 501 pseudoephedrine 28 Pseudomonas endotoxin 423 psilocybin 30 puberty, delayed 284 public perceptions, gene therapy 488 pulmonary delivery 67-8 pulmonary embolism 385, 386 Pulmozyme 393, 507 pupil dilation 29 Puregon 501 purification 57 purified water 105-7, 109 purine metabolism 395, 396 purine nucleoside phosphorylase 54 pyridoxal 5'-phosphate 357 pyrogens 173-9
qualification 184
quality control identity tests 57
Quil A 459
quinestrol 17, 18
quinine 3, 28, 29, 30
rabbit
antibody production tests 182 pyrogen test 176 rabies
immunoglobulin 406 vaccine 438 radiolabelling
antibody fragments 432 monoclonal antibodies 420-1 radiotherapy 274 randomized control studies 76 Rapilysin 381, 384, 500 rapporteurs 86 Ras/MAPK signalling 290 Ras pathway 286 rat poisons 375 reactive oxygen species 215 reactor design 134 Rebetron 209, 503
548 INDEX
Rebif 209, 213, 503
recombinant DNA technology 5, 7, 515-20
recombinant protein 4
Recombinate 366, 500
Recombivax 442, 503
records 111
rectal cancer 421
rectal delivery 69
red blood cells 353
ReFacto 366, 500
Refludan 378, 507
refractile bodies 114
Regranex 289, 507
regulation 84
regulatory authorities 43, 78-89, 510-11 regulatory inspectors 43 Remicade 416, 506 renal cancer 230
renal effects, insulin-like growth factors 284 ReoPro 416, 505 Replagal 395, 507
replication-defective retroviral vectors 121 reproductive effects
insulin-like growth factors 284-5 pre-clinical trials 71 reserpine 28 reshaping 432
respiratory tract, protection 388 Retavase 381, 384, 500 reteplase 384-5 retinol-binding protein 356 retrospective validation 184 retroviruses
cancer induction 427 vectors 468-72 Revasc 379, 507 reverse osmosis 107 reverse-phase HPLC 167-8 rhesus antigen 406-7 rheumatoid arthritis anaemia 271 cytokines 196 Enbrel treatment 252 IL-1 treatment 234-5 monoclonal antibodies 434 tumour necrosis factor 251 wound healing 278 rhodniin 377 ribozymes 494 rice 122 ricin 423
Rickettsia prowazekii 440 rifamycins 38 ring-main 107 cleaning 104 Rituxan 416, 505
RNA 47-8 double-stranded 204 viruses, cancer induction 427 RNase F 206 RNase H 491 RNase L 206 Roche 5, 416, 506 rodent ulcers 279 Roferon A 209, 502 roller bottles 134 Romanowsky stain 191 Rosetta Stone approach 47 rotavirus vaccine 438 RP-HPLC 167-8 rubella vaccine 438, 439
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