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biopharmaceuticals biochemistry and biotecnology - Walsh G.

Walsh G. biopharmaceuticals biochemistry and biotecnology - John Wiley & Sons, 2003. - 572 p.
ISBN 0-470-84327-6
Download (direct link): biochemistryandbiotechnology2003.pdf
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multiple drug resistance (MDR-1) gene product 486
multiple sclerosis IFN-b 213-14 tumour necrosis factor 251 mumps vaccine 437, 439 murabutide 457 muramyl dipeptide 456-7 muramyl tripeptide 457 murine monoclonals, antigenicity 428-9 mutagenicity 72 mutual recognition 88 mycobacteria 230 Mycobacteria leprae 230 Mycobacteria tuberculosis 230 myelin sheath 295 myeloid leukaemia 258, 263 Mylotarg 417, 423-4, 506 myocardial infarction (heart attack) 381 Alteplase 383 anticoagulants 372 monoclonal antibodies 433 plant alkaloids 30 streptokinase 385 MyoScint 416, 505 myotrophin 298
N-terminal sequencing 171-3 NADPH oxidase system 215 nafarelin acetate 345 naked plasmid DNA 476 Namalwa cell line 209 nasal decongestant 30 nasal delivery 68-9
natural killer (NK) cells 191, 228, 229, 417 necrosin 246 necrosis 249 neomycin 38
Neorecormon 268 , 270, 502 NeoRx 416, 505 Nepogen 261
nerve growth factor 293, 294, 296, 299
nervous system 295
Nespo 270, 502
Neulasta 261, 263, 502
Neumega 224, 241, 503
Neupogen 11, 502
neurites 295
neurodegenerative disease 285, 298-300 neuroendocrine transducers 325 neurons 295 insulin-like growth factors 285 neurotrophic factors 278, 293-300 neurotrophin-3 (NT-3) 294, 296 neurotrophin-4/5 (NT-4/5) 294, 296, 299 neurotrophin-6 (NT-6) 294, 296
INDEX 545
neurotrophins 294, 296
neutral red 72
neutropenia 262, 263
neutrophils 192
new chemical entities 86
new drug application (NDA) 80, 82-4
Niemann-Pick disease 483
non-Hodgkin’s lymphoma 230
non-immune libraries 414
non-obviousness 62
non-randomized concurrent clinical trials 76
noradrenaline 21-2, 23, 24
Norditropin 329, 501
norepinephrine 21-2, 23, 24
norethinodrone 20
norethisterone 19
normal immunoglobulin 406, 407
Novartis 416, 505
novelty 62
Novo Nordisk 315, 319, 323, 329, 366, 371, 499, 500, 501, 511 Novolin 315, 500 Novolog 315, 500 Novolog mix 70/30 315, 500 Novomix 30 500, 315 NovoRapid 315, 500 NovoSeven 366, 371, 499 nuclear magnetic resonance 50 nuclear transfer 121 nucleic acid therapeutics 463-97 null cells 191 Nutropin 329, 501 Nutropin AQ 329, 501 N. V. Organon 501
obesity 330 obstetrics 27
b-oestradiol 15, 17, 18, 336, 337, 338 oestriol 15, 336, 337 oestrogens 15-16, 17, 333, 336 oestrone 15, 17, 18, 336, 337 Ogawa 439
oil-based emulsion adjuvants 455-7
oil-in-water adjuvant 456 old age 331
2'-5' oligoadenylate synthetase 204, 205, 206
oligodendrocytes 295
oligonucleotide arrays 48
oligonucleotides, anti-sense 489-94
oncofetal antigens 427-8
oncogenes 179
OncoScint CR/OV 416, 505
one-time, single-hit gene transfer 468
Ontak 232, 507
OP-1 implant 83-4
open loop systems 320
operational qualification 184 opium 29
Optisulin 315, 318, 501 oral contraceptives 16, 19 oral delivery 66-7 vaccines 123 Organon Teknika 417, 501, 506 orphan medicines 86 Ortho Biotech 270, 416, 502, 505 Ortho-McNeil Pharmaceuticals 507 Orthoclone OKT3 416, 434-5, 505 osmotic pressure 107 osteoblasts 283 osteoclasts 284 Osteogenic protein 1 507 osteoporosis 16, 284 osteosarcoma-derived growth factor 287 ovarian adenocarcinoma 428 ovarian cancer 230, 486 ovarian cycle 333 ovaries 334 Ovidrelle 501 Ovitrelle 343, 501 ovulation 331, 333 ovum 334 oxidation 145-7
oxygen-carrying blood substitutes 357-8 oxymetholone 15, 16 oxytocin 13 ozone 109
P-55 249 P-75 249 p24 451 p40 458 p53 486 P75 297 p97 452 PABA 6, 7
packaging instructions 110-11 packing 158-9 packing cell 468, 471 packing sequence (C) 468 Paget's disease 347 pan-neurotrophin-1 300 pancreas, artificial 320 pancreatin 399 pancreatitis 399 pancrelipase 13 papain 398, 399 papaverine 30 papilloma virus family 213 papovaviruses 427 paracellular transport 68 paracetamol 2 parenteral administration 66
546 INDEX
Parkinson’s disease 298, 299-300 paromycin 38 parvoviral infection 219 passivation 109 passive immunization 403 Pasteur Merieux MSD 442, 504 patenting 9, 57, 61-5, 510 PD 153035 287 peanut oil 456 pecacuanha 3 Pegasys 209, 503 PEGIntronA 209,211, 502 PEGylated filgrastim 261, 263 PEGylated interferons 211 pencillins 4, 34-7 pepsin 399 pepstatin A 144 peptic ulcers 279 peptides 4 antibiotics 39 chemical synthesis 58 hormones 13 libraries 56 mapping 170, 171 vaccines 444-5 performance-enhancing drugs 284 performance qualification 184 perikaryon 295
peripheral neuropathy 298, 299 pertussis vaccine 437 Peterson method 163 Pfizer 68
phage display technology 412-14 phagemids 413 phagocytes 215
Pharmaceutical Affairs Bureau (PAB) 88 pharmaceutical companies 9, 511 see also specific companies pharmaceutical industry, history 3-5 pharmaceutical products 1 Pharmaceutical researchers and manufacturers of America 509 Pharmacia 329, 501 pharmacodynamics 69-70 pharmacogenetics 51-2 pharmacogenomics 52 pharmacokinetics 69-70 pharmacopoeia 93-4, 515-26 Pharmacos 510 phase I-IV trials 73-4 phenylketonuria 483 phosphatidyl inositol 4,5 biphosphate 290 2'-5'-phosphodiesterase 206-7 phosphoinositol biphosphate (PIP2) 286 phospholipase C 286 phospholipase C-g 290
phosphoramidite method 494
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