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biopharmaceuticals biochemistry and biotecnology - Walsh G.

Walsh G. biopharmaceuticals biochemistry and biotecnology - John Wiley & Sons, 2003. - 572 p.
ISBN 0-470-84327-6
Download (direct link): biochemistryandbiotechnology2003.pdf
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International Conference on Harmonization (ICH) 89, 510 International Patent Cooperation Treaty 63 Internet addresses 509-13
Intervet 12, 504, 505 intracellular immunization 487 Intron A 11, 209,211, 502 investigational new drug application (IND application) 80-2 ion exchange chromatography 142 HPLC format 168 ipecac 28 ischaemia 278
ISIS Pharmaceuticals 494, 507 islet cell transplant 321 isoelectric focusing 165-6 isophane insulin 310, 317 isoprene 31 isothiazolones 243 Ivax 10
JAK-STAT pathway 199-203 Janssen-Cilag 507 Janus kinases (JAKs) 200 Japan, drug registration 88 Japanese encephalitis vaccine 437 Jeryl Linn strain 439 Johnson & Johnson 11 Jurkat leukaemia cell line 228 juvenile-onset diabetes 304, 305
kallikrein 360 kanamycin 38 kaolin 386 Kaposiís sarcoma 272 keratinocytes 224 ketamine 2 kidney disease 284 kidney failure 270-1 Kineret 234-5, 503 knock-out animal studies 47 Kogenate 366, 499 kringle-1/2 domain 383
labelling 110-11, 158-9 labour, premature 342 b-lactams 35 lactase 400 lactation 331 lactose intolerance 400 Lactrodectus mactans 408 LAL-based assay 176-8 Lantus 315, 318, 501 large, simple clinical trial 77 large granular lymphocytes 191 Laron type dwarfs 283 laryngeal papillomatosis 213 LD50 71
lead compounds 53
lectin affinity chromatography 142
INDEX 543
leeches 375
Legionella pneumophilia 231 legionnairesí disease 231 leishmaniasis 216, 245 leprosy 216, 230 Leptospira antisera 406 vaccine 437 lethal dose 71
Leuconostoc mesenteroides 355 leukaemia 30, 263
see also specific leukaemias leukaemia inhibitory factor (LIF) 263, 278, 297 Leukine 261, 263, 502 leukocyte adhesion deficiency 483 leukocyte function-associated antigen-1 (LFA-1) 434 leukocytes 191-2 LeukoScan 416, 506 leuprorelin acetate 345 levamisole 2 Leydig cells 335, 336 LFA-1 434
LH/FSH-releasing factor 332
libraries 56, 413-14
LIF receptor 297
ligand leakage 368
Ligand Pharmaceuticals 507
light chains 418
limonene 32
Limulus amoebocyte lysate (LAL) test 176-8 lipid A moiety 176 lipoplexes 477 lipopolysaccharide (LPS) adjuvanticity 458 monoclonal antibodies 434 pyrogenicity 114, 116, 174-6 liposomes 389-90, 459 Liprolog 315, 500 liquid format 142 Listeria monocytogenes 231 listeriosis 231 LNGFR 297
local anaesthetic additives 23 local toxicity tests 72 lockjaw 408
long terminal repeats 468 loop system 107, 109 Lowry method 163 LSD 30
lung surfactant 67, 260 luteinizing hormone (LH) 14, 331-5, 340-2 recombinant 343 luteinizing hormone-releasing hormone (LHRH) 332, 338 Luveris 343, 501 Lymerix 442, 503
lymphocyte-activating factor (LAF) 232 lymphocytes 191
lymphokine-activated killer cells (LAKs) 228, 230
lymphoma 232
lymphotoxin 246
lyophilization 155
D-lysergic diethylamide 30
Mabcampath 417, 506 Mabthera 417, 506 MacLeod, John 305 macrolides 38
macrophage colony-stimulating factor (M-CSF) 258, 259, 261-3 macrophage cytotoxic factor 246 macrophage cytotoxin 246 macrophages 191, 224, 229, 417 Madagascar periwinkle 30 magic bullet 414, 421 malaria IL-2 230 IL-12 245 quinine 3, 30 vaccine 436, 440 Malaysian pit viper 5 malnutrition 278
Maloney murine leukaemia virus (MoMuLV) 468 mammalian cell culture systems 133-4 mammary-specific expression 118-21 mannitol 152
mannose-6-phosphate receptors 395
manufacturing 93-187, 527-32
manufacturing facility 97-111
manufacturing formulae 110-11
manufacturing records 111
MAP kinase pathway 307
Maple syrup disease 483
Martindale, The Extra Pharmacopoeia 94, 95
mass spectrometry 168
master cell bank 127
measles
immunoglobulin 406 vaccine 437, 439 Medeva Pharma 442, 504 medical devices 83 MedImmune 416, 506 medroxyprogesterone acetate 19, 20 megakaryocyte growth and development factor (MGDF) 275 megakaryocytes 240, 273 megestrol acetate 19, 20 melanoma
dacarbazine 33 IL-2 230
Tecnemab-K-1 421-2 vaccine 452
544 INDEX
meningococcal vaccine 437, 440 menopausal symptoms 16 menotrophin 340, 341 menstruation 333 disorders 17 menthol 32 Merck 442, 503 mercury 3
Merrifield solid phase synthesis method 58 mestranol 17, 18
metal chelate chromatography 142 metalloprotease inhibitors 252 Metalyse 381, 385, 500 methicillin 36
methionine oxidation 145, 146, 147 methotrexate 424 methylprednisolone 23, 24 methyltestosterone 15, 16 microbes
cell fermentation 129, 131-3 contaminants 180-1 as pharmaceutical source 33-9, 53-4 Microbix 10 microcarriers 134 Microgenes Sys. Inc. 451 b2-microglobulin 356 microheterogeneity 150 Micromonospora echinospora spp. calichensis 423
microspheres 67, 389, 390 Micrurus fulvius antivenin 408 milk, transgenic animals 118-21, 379 Millennium Pharmaceuticals 417, 506 mineral adjuvants 455 mineral oil 456 mineralocorticoids 19-20 miroprostol 2 Mixtard 315, 501 MMR vaccine 439 molecular mass 178-9 monoclonal antibodies 4, 8, 409-35
approved biopharmaceuticals 11, 416, 505-6 hybridoma technology 5, 409-12 radiolabelled 420-1 screening 412-14 mononuclear phagocytes 191 monophosphoryl lipid A (MPL) 458 Monotard 315, 501 morphine 28, 29-30 motion sickness 29 motor neuron disease 285 motor neurons 295 mouse antibody production tests 182 mucoadhesive delivery systems 67 mucopolysaccharides 372 mucopolysaccharidosis type I/type VII 483
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