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biopharmaceuticals biochemistry and biotecnology - Walsh G.

Walsh G. biopharmaceuticals biochemistry and biotecnology - John Wiley & Sons, 2003. - 572 p.
ISBN 0-470-84327-6
Download (direct link): biochemistryandbiotechnology2003.pdf
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Helixate NexGen 366, 499 helminths 242 HEPA filters 98-9 validation 183 Hepacare 442, 504 heparin 353, 372-5 hepatitis, IFN-a 212-13 hepatitis A
immunoglobulin 406 vaccine 437, 439 hepatitis B 352 IFN-a 212-13 immunoglobulin 406, 407 monoclonal antibodies 434 surface antigen (HBsAG) 13, 122, 441, 444 vaccine 437, 440, 441 hepatitis C 212, 352 hepatitis D 212 Herceptin 416, 506 herpes simplex virus 437 heterologous protein production 112 Hexavac 442, 504
high-efficiency particulate air (HEPA) filters 98-9 validation 183 high molecular mass kininogen (HMK) 360 high pressure liquid chromatography (HPLC)
140, 167-8 HILDA 263 hinge region 418 hirudin 122, 372, 375, 377-9 histiocytes 191 historical control trials 76 HIV anaemia 272 blood transmission 352 monoclonal antibodies 434 see also AIDS Hodgkin’s disease 30 Hoechst AG 4, 315, 500 Hoechst Marion Roussel 507 Hoffman-La Roche 209, 416, 417, 502, 503, 505, 506
homogeneity determination 165 homogenization 136-7 Hoogsteen base pairs 494 hormone replacement therapy 17 hormones 11, 13, 303-50, 500-2
INDEX 541
Howmedica 507 Humalog 315, 500
human antimouse antibodies (HAMA) 428-9 human chorionic gonadotrophin (hCG) 13, 331-5, 340-2 recombinant 343 human genome project 45-6 human growth hormone 13, 147, 324-31 human insulin crb 310, 313 human insulin emp 310 human insulin prb 310, 313 human menopausal gonadotrophin (HMG) 340 human papilloma virus 213, 427 human serum albumin (HSA) 13, 122, 150, 151, 355-6
human T-cell lymphotrophic viruses I and II 352, 427
humanized antibodies 432 Humaspect 417, 429, 506 Humatrope 329, 501 Humulin 8,113, 315, 500 Huntington’s disease 299 hybrid trial design 77 hybridization 48 hybridoma technology 5, 409-12 hydrocortisone 21, 23 hydrogen peroxide 215,397 hydrolysis 143
hydrophobic interaction chromatography 142
hydroxamic acid 252
hydroxyapatite chromatography 142
hydroxyl radical 397
hyperammonemia 483
hypercalcaemia 347
hypercholesterolaemia 483, 484
hypersensitivity 238, 245, 404, 405
hyperuricaemia 395
hypervariable regions 418
hypochlorous acid 215
hypoglycaemia 322
hypogonadotrophic hypogonadism 342
hypotension 23
hypoxia 267-8
ICAM-1 434
ICE 235
IDEC Pharmaceuticals 416, 417, 505, 506 iduronic acid 373
IGF binding proteins (IGFBPs) 279, 282
ILEX 417, 506
imide formation 145
immortalized B lymphocytes 429
immune globulins 407
immune interferon 198
immune libraries 413-14
Immunex 10, 11, 261, 502, 507
immunity, TNF-a 248-9 Immuno-Ag 451
immunoaffinity chromatography 142 immunoassays
contaminant detection 168-9 potency determination 162-3 viral assays 182 immunogenicity 160 immunoglobulin G (IgG) 403 immunoglobulins 403, 404-8, 418 Immunology Link 513 Immunomedics 416, 505, 506 immunoscintigraphy 420, 433 immunostimulatory complexes (ISCOMS) 459 immunosuppression 20, 231, 424 immunosurveillance 415 immunotoxicity 72 impeller 129
in vitro fertilization (IVF) 341 Inaba 439 inclusion bodies 114 indicator molecule 72 Indimacis-125 416, 428, 506 Inductos 507 Infanrix-Hep B 442, 503 Infanrix-Hexa 442, 504 Infanrix-Penta 442, 504 infectious disease anaemia 272 IL-2 230-1
monoclonal antibodies 433-4 Infergen 209,211-12, 503 infertility 339, 341 inflammation, TNF-a 248-9 influenza vaccine 437 information technology 111 infusion systems 320 inhibins 332, 334, 337-8, 340 recombinant 343-4 inositol 152
inositol triphosphate (IP3) 286, 290 insect cell-based systems 123-4 installation qualification 184 Institute for Genomics Research 512 Insulatard 315, 501 insulin 2, 4, 13, 278, 303-21 biphasic 310, 317 conventional 309, 310 delivery systems 320 engineered 317-19 molecule 304, 306-7 - producing cell transplants 321 product formulation 314, 316-17 production 307, 309-11 products, glossary 310 purified/highly purified 310,311
542 INDEX
Insulin (continued)
receptor 280, 307, 308 recombinant 113, 312-14 signal transduction 307 single peak 310 Insulin Aspart 315, 318 insulin-dependent diabetes mellitus 304, 305 insulin glargine 315, 318 insulin-like growth factors (IGF-1 and IGF-2) 278, 279-85, 298, 325, 327, 331 Insulin Lispro 315, 318, 319 Insuman 315, 500
intercellular adhesion molecule 1 (ICAM-1) 434 interferon-stimulated response elements (ISREs) 198, 203 interferons (IFNs) 11, 196-219 approved biopharmaceuticals 502-3 bioassays 162 biological effects 203-7 biotechnology 207-10 IFN-a 122, 196, 197-8, 210-13, 520-6 IFN-b 122, 196, 197, 198, 213-14 IFN-g 196, 197, 198, 214-16, 278 IFN-g 1B 216 IFN-o 219 IFN-t 219
JAK-STAT pathway 202-3 PEGylated 211 receptors 199 signal transduction 198-9 toxicity 216-18 type I/type II 197 veterinary use 9, 12, 219 interleukin-1 receptor antagonist (IL-1Ra) 234 interleukin-1bconverting enzyme (ICE) 235 interleukins (ILs) 223-46, 278 approved biopharmaceuticals 11, 502-3 haemopoietic growth factors 257-8 IL-1 232-5 IL-1a 232-3 IL-1Ra 234 IL-1b 232-3 IL-2 224, 225-32 IL-3 235-6, 257-8 IL-4 224, 236-8 IL-5 241-3 IL-6 238-40 IL-10 224 IL-11 240-1 IL-12 244-6 IL-13 224 IL-18 224
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