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biopharmaceuticals biochemistry and biotecnology - Walsh G.

Walsh G. biopharmaceuticals biochemistry and biotecnology - John Wiley & Sons, 2003. - 572 p.
ISBN 0-470-84327-6
Download (direct link): biochemistryandbiotechnology2003.pdf
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excipients 72, 140, 143, 150-2, 156 exo-proteases 144 ExPASy 512 Exubera 68
F(ab) 432 F(ab)2 432
Fab fragments 418, 432 Fab2 418
Fabrazyme 395, 507
Fabry’s disease 395
factor I 359, 361-2
factor Ia 361
factor II 359, 361
factor IIa 361
factor III 359
factor IV 359
factor V 359
factor VII 359
factor VIIa 371
factor VIII 359 360, 366-71
factor IX 359, 360, 371
factor X 359, 360, 361
factor XI 359, 360
factor XII 359, 360
factor XIIa 360
factor XIII 359, 363, 365, 371
factorial design 77
far UV method, protein assay 163, 173 Fasturtec 397, 507 Fc 418
feed batch approach 133
female reproductive cycle 333
fetal development, insulin-like growth factors 283
a-fetoprotein 428
Fevaxyl Pentafel 12
Fevaxyn Pentofel 504
fibrin 361, 381
fibrin-stabilizing factor 359
fibrinogen 359, 361-2
fibrinolysis 380-1
fibroblast growth factors (FGF) 278, 289-90, 291
INDEX 539
fibroblasts 224 fibrokinase 381 filgrastim 261, 262-3 filtration 107 final product analysis 159-85 fill 153-5
formulation 140, 142 production 124-59 finger domain 383
finished product pharmaceutical facilities 1
first-pass metabolism 66
first to invent 62
flatulence 399
flavonoids 30-3
Fleming, Sir Alexander 34
fludrocortisone acetate 23, 24
fluorocarbons 357
5-fluorocytosine 426
fluosol 357
‘fogging’ 102
follicle stimulating hormone (FSH) 13, 331-5, 340-2 recombinant 342-3 follicles 333, 334 Follistim 343, 501
Food and Drug Administration (FDA) 78-84, 510 Forcaltonin 502
Fort Dodge Laboratories 12, 504
framework regions 418
framycetin 38
freeze-drying 151, 155-8
Freund’s complete adjuvant (FCA) 455-6
Freund’s incomplete adjuvant (FIA) 456
FRS2 290
fruit, vaccines in 123
fucosidosis 483
functional genomics 46-7
fungal production systems 117-18
funnel-web spider 409
Furegon 343
Fv 418, 432
gag 468, 487 galactosemia 483 a-galactosidase 395, 399 b-galactosidase 400 Galenus Mannheim 381, 500 gas gangrene antitoxins 406 gastric acid secretion 27 Gaucher’s disease 393, 394, 483 gel-filtration chromatography 142
protein-based contaminant removal 160 gelatin 357 gelonin 423 gene chips 47-8
gene gun 476
gene neighbourhood method 47 gene patenting 65 gene therapy 4, 10-11, 463-88 AIDS 486-8
anti-sense oligonucleotides 493 cancer 485-6 genetic disease 482-5 vaccines 488
vector systems 464, 465, 467, 468-79 Genemedix 10
Genentech 8, 10, 209, 216, 313, 328, 329, 381, 393, 416, 451, 452, 500, 501, 502, 505, 506, 507, 511 general safety tests 183 generic biopharmaceuticals 9-10 genetic disease, gene therapy 482-5 genetic engineering 5, 8 vaccines 441-7 Genetics Institute 366, 499, 500, 503, 507 genital warts 213 genome database 512 genomics 45-52 Genotropin 329, 501 gentamicin 38
Genzyme 11,394,395, 501, 507,511 GH-binding proteins (GHBPs) 326 gigantism 327
glass transition temperature 158 glass vials 182 Glaxo 5
Glaxo SmithKline 442, 504 glial derived neurotrophic factor (GDNF) 297, 298, 299-300 glioma-derived growth factor 287 gliomas 290 g-globulins 356 Glucagen 323, 501 glucagon 13, 321-4 glucocerebrosidase 13, 122, 393-4 glucocorticoids 19, 20, 22 glucosamine 373 glucuronic acid 373 glutamic acid 145 glutarimides 145 b-glycan 293 glycerol 152 glycine 151
glycogen storage deficiency type 1A 483 glycoprotein glycosylation patterns 147-50 glycosaminoglycans 335, 372 glycosylation 114 goats’ milk 118, 379 gonadorelin 13, 332
gonadotrophin releasing hormone (GnRH) 332, 338, 340, 345 analogues 345
540 INDEX
gonadotrophins 14, 331-48 recombinant 342-4 veterinary use 339, 344-5 Gonal F 343, 501 good manufacturing practice (GMP) blood products 351 depyrogenation 174, 178 guides to 94-7
monoclonal antibodies 411-12 goserelin acetate 345 gout 395 gp41 449 gp120 448, 451 gp130 297 gp160 451 gramicidin 39
granulocyte-colony stimulating factor (G-CSF) 258-9, 261-3 granulocyte-macrophage colony stimulating factor (GM-CSF) 122, 258, 259-63 granulocytes 192 granuloma 215-16 granulosa cells 334, 335, 336, 338 growth, insulin-like growth factors 283-4 growth cone 295 growth factors 277-301
growth hormone releasing factor (GHRF) 324, 325
growth hormone releasing hormone (GHRH) 324 growth hormone releasing inhibiting hormone (GHRIH) 324, 325 GTC Biotherapeutics 121 gynaecology 27
haematocrit 270 haematopoietins 192 haemoglobin 357-8 haemoglobinopathies 483 haemolytic disease of the newborn 353, 407 haemopexin 356 haemophilia A 366-71, 483 haemophilia B 366, 371, 483 Haemophilus influenzae immunoglobulin 406 vaccine 437, 440 haemopoiesis 255
haemopoietic growth factors 11, 255-76, 502
haemopoietic stem cells 255
haemostasis 358-89
Hageman factor 359
hairy cell leukaemia 210
hamster antibody production test 182
hapatocyte stimulatory factor III 263
haptoglobin 356
Harvard mouse 65
hayfever 30
HBVAXPRO 442, 504
heart attack see myocardial infarction
heart conditions 3
heart failure 33
heat treatment
depyrogenation 178 viral inactivation 181 heavy chains 418 Helixate 499
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