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biopharmaceuticals biochemistry and biotecnology - Walsh G.

Walsh G. biopharmaceuticals biochemistry and biotecnology - John Wiley & Sons, 2003. - 572 p.
ISBN 0-470-84327-6
Download (direct link): biochemistryandbiotechnology2003.pdf
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cleaning, decontamination and sanitation (CDS) 101-4 validation 185 cleaning in place (CIP) 102
clinical trials 73-8 protocol 77, 78 clomiphene 16, 18 closed-loop system 320 Clostridium histolyticum 398 Clostridium tetani 408 clotting disorders 365-6 clotting factors 358, 359 coagulation pathway 358-65 coca leaves 29 cocaine 28, 29-30 codeine 28, 29 collagenase 398 Collip, James 305 colloidal plasma expanders 354 colon cancer 230, 421 colony stimulating factors 258-63, 278 combinatorial peptide libraries 56-7 Committee for Orphan Medicinal Products (COMP) 86 Committee for Proprietary Medicinal Products (CPMP) 85 Committee for Veterinary Medicinal Products (CVMP) 86 computer modelling 54 computerized records 111 Comvax 442, 503 concurrent validation 184 Congene 10 constant fragment 418 constant regions 418 containers 182
contaminant-clearance validation 184-5 contraceptives 16, 19, 344 control groups 75 Coomassie blue G-250 163, 164 coronary angioplasty 357 coronary heart disease 372 coronary thrombosis 372 corpus luteum 333
corticosteroids 13, 19-20, 21, 22, 23, 24
corticotrophin 19
cortisol 21, 23
cortisone 21
costs, gene therapy 488
cough suppressant 30
coumaran 376
coumarins 33
Cowpox virus 196
Creutzfeldt-Jakob disease (CJD) 328
CrK 290
cross-over design 77 Crotalidae antivenin 408 cryoprotectant 151, 156 cryptorchidism 342 CSF-1 259
INDEX 537
CSF-a 259 CSF-b 258
cutaneous T cell lymphoma 232 cyanogen bromide 170 cyclosporin A 231 cysteine knot cytokines 192 cysteine oxidation 145, 146 cystic fibrosis
digestive aids 398, 399 DNase 392-3 gene therapy 483, 484-5 cystic fibrosis transmembrane conductance regulator (CFTR) 392, 484 Cytogen 416, 505 cytokines 189-96
see also specific cytokines cytomegalovirus
blood transmission 352 immunoglobulin 406 retinitis 494 vaccine 437 cytopathic effect inhibition assay 162
10-DAB 32 dacarbazine 33 danazol 15, 16 debriding agents 397-8 decorsin 377 decubitus ulcers 279 deep vein thrombosis 385, 433 defleecing 287 deionization 106 delivery systems 66-9 delmadinone acetate 20 dendrites 295 deoxycorticosterone 21 deoxycortone acetate 23, 24 design qualification 184 dexamethasone 2, 23, 24 dextrans 354-5 diabetes
hypoglycaemia 322 IGF-1 284
islet cell transplants 321 peripheral neuropathy 298 tumour necrosis factor 251 type I 304, 305 type II 284, 305 ulcers 278, 279, 289 diabetes insipidus 305 diabetes mellitus 304, 305 diacylglycerate production 338 diacylglycerol (DG) 286, 290 Dialpha 358 diazoxide 2
dicoumarol 28, 33, 372, 375, 376
2'-3'-didoxynosine 54
diethylstilboestrol 15, 18
digestive aids 398-9
digestive proteases 66
digitalis 3, 33
digitoxin 28, 33
digoxin 28, 33
dihydrotestosterone 336
2,3-diphosphoglycerate (2,3-DPG) 357
diphtheria
antitoxin/immunoglobulin 406 vaccine 437, 440 directive 84
disease transmission 351-3 disinfectants 102 distillation 107 disulphide exchange 147 DNA arrays 47, 48 clearance studies 185 contaminants 179 patenting 65 viruses 427 DNase 392-3 documentation 109-11 Dolly the sheep 121 Dompe Biotec 270, 502 donated blood 351, 404 dot-blot assay 179 double-stranded RNA 204 downstream processing 124-5, 134-40 doxorubicin, phenoxyacetamide derivatives 426 Drug Information Association (DIA) 509 drugs
design 54-6 development 43-91 discovery 44-57 manufacturing 93-187, 527-32 dry heat 178
dwarfism 283, 327, 328-30 dye affinity chromatography 142 dye-binding 164 dyes, artificial 4 dysentery 3
E1/E2 473
Ecokinase 113, 381,384, 500
ecosanoids 23
edible vaccines 123
Edman degradation 171, 172
EDTA 144, 179
egg cell 334
egg white 122
eIF-2a protein kinase 204, 207, 208 elderly, wounds 278 electronic records 111
538 INDEX
Eli Lilly 5, 8, 313, 315, 319, 324, 329, 500, 501, 507, 511 Elitex 507 elution 368-9 embolism 372 Embrel 11 emphysema 388, 483 enabling publication 62 Enbrel 252, 507 encapsulation 67, 389, 390 endocytosis 479 endogenous pyrogens 174, 232 endometrial cancer 17 endometriosis 17 endo-proteases 144 endo-RNase 206 endosomal escape 479 endotoxin 174, 176 antibodies 406 Engerix-B 441, 442, 503 enteric coat 67 env 468, 487 enzymes 2, 132, 389-400 eosinophils 192, 224, 241-2 ephedrine 29, 30
epidermal growth factor (EGF) 192, 278, 285-7, 383
epinephrine 21-2, 24 epithelial cells 213 epitope 409 Epogen 11, 270, 502 Epstein-Barr virus 196, 427, 429 Eptacog a-activated 371 equipment
cleaning, decontamination and sanitation 102-4 validation 183 ergometrine 30 ergot alkaloids 30 erythroblastosis fetalis 407 erythrocytes 264 erythromycin 38 erythron 264
erythropoietin (EPO) 122, 264-73, 278 bioassays 162 Eschericia coli 112-16 ethics
gene therapy 488 randomized control studies 76 ethinyloestradiol 15, 17, 18 ethnobotany 53 ethynodiol diacetate 19, 20 etoposide 426
EU Guide to Good Manufacturing Practice for Medicinal Products 95, 96 European Association of Pharma Biotechnology (EAPB) 509
European Bioinformatics Institute (EBI) 512 European Commission 84 European Directorate for the Quality of Medicines 511 European Federation of Biotechnology 510 European Medicines Evaluation Agency (EMEA) 85-6, 510 European patent directive 65 European Patent Organization 63 European pharmacopoeia, monographs 515-26 European regulations 84-8 European Society for Gene Therapy 513 European viper venom antisera 408 Europharm 507
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