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biopharmaceuticals biochemistry and biotecnology - Walsh G.

Walsh G. biopharmaceuticals biochemistry and biotecnology - John Wiley & Sons, 2003. - 572 p.
ISBN 0-470-84327-6
Download (direct link): biochemistryandbiotechnology2003.pdf
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Produced in E. coli)
Neumega (rIL-11, lacks N-terminal Genetics Institute proline of native human molecule.
Produced in E. coli)
Kineret (anakinra; rIL-1 receptor Amgen
antagonist produced in E. coli)
Vaccines
Recombivax (rHBsAg produced Merck
in S. cerevisiae)
Comvax (Combination vaccine, Merck
containing rHBsAg produced in S. cerevisiae as one component)
Engerix B (rHBsAg, produced in SmithKline
S. cerevisiae) Beecham
Tritanrix-HB (Combination vaccine, SmithKline
containing rHBsAg, produced in Beecham
S. cerevisiae as one component)
Lymerix (rOspA, a lipoprotein SmithKline
found on the surface of Borrelia Beecham
burgdorferi, the major causative agent of Lyme’s disease. Produced in E. coli)
Infanrix-Hep B (Combination SmithKline
vaccine, containing rHBsAg Beecham
produced in S. cerevisiae as one component)
Relapsing multiple sclerosis Chronic hepatitis C
Relapsing/remitting multiple sclerosis Chronic hepatitis C
Hepatitis B, C, and various cancers Hepatitis B and C
Hepatitis C
Vet. (reduce mortality/ clinical signs of canine parvovirus) Renal cell carcinoma
1997 (EU), 1996 (USA)
1997 (USA), 1999 (EU)
1998 (EU), 2002 (USA)
(1999 USA)
2000 (EU)
2000 (EU)
2002 (EU, USA)
2001 (EU)
1992 (USA)
Prevention of 1997 (USA)
chemotherapy-induced thrombocytopenia Rheumatoid arthritis 2001 (USA)
Hepatitis B prevention 1986 (USA)
Vaccination of infants 1996 (USA)
against Haemophilus influenzae type B and hepatitis B Vaccination against 1998 (USA)
hepatitis B Vaccination against 1996 (EU)
hepatitis B, diphtheria, tetanus and pertussis Lyme disease vaccine 1998 (USA)
Immunization against 1997 (EU) diphtheria, tetanus, pertussis and hepatitis B
Continued
504 BIOPHARMACEUTICALS
Product
Company
Therapeutic indication Date approved
Infanrix-Hexa (Combination SmithKline
vaccine, containing rHBsAg Beecham
produced in S. cerevisiae as one component)
Infanrix-Penta (Combination vaccine, containing rHBsAg produced in S. cerevisiae as one component)
Ambirix (Combination vaccine, containing rHBsAg produced in S. cerevisiae as one component)
Twinrix (Adult and paediatric forms in EU. Combination vaccine containing rHBsAg produced in S. cerevisiae as one component)
Primavax (Combination vaccine, containing rHBsAg produced in S. cerevisiae as one component)
Procomvax (Combination vaccine, containing rHBsAg as one component)
Hexavac (Combination vaccine, containing rHBsAg produced in S. cerevisiae as one component)
SmithKline
Beecham
Glaxo SmithKline
SmithKline Beecham (EU), Glaxo SmithKline (USA)
Pasteur Merieux MSD
Pasteur Merieux MSD
Aventis Pasteur
Triacelluvax (Combination vaccine containing r(modified) pertussis toxin)
Hepacare (r S, pre-S and pre-S2 hepatitis B surface antigens, produced in a murine cell line)
HBVAXPRO (rHBsAg produced
in S. cerevisiae)
Porcilis Porcoli (combination vaccine containing r E. coli adhesins)
Fevaxyn Pentofel (Combination vaccine containing r feline leukaemia viral antigen as one component)
Porcilis AR-T DF (Combination vaccine containing a modified toxin from Pasteurella multocida expressed in E. coli)
Chiron SpA
Medeva Pharma
Aventis Pharma
Intervet
Fort Dodge Laboratories
Intervet
Immunization against diphtheria, tetanus, pertussis, polio,
H. influenzae b and hepatitis B Immunization against diphtheria, tetanus, pertussis, polio and hepatitis B Immunization against hepatitis A and B
Immunization against hepatitis A and B
2000 (EU)
2000 (EU)
2002 (EU)
1996 (EU) (adult),
1997 (EU) (paediatric),
2001 (USA)
1998 (EU)
Immunization against diphtheria, tetanus and hepatitis B Immunization against 1999 (EU)
H. influenzae type B and hepatitis B Immunization against 2000 (EU)
diphtheria, tetanus, pertussis, hepatitis B, polio and H. influenzae type b
Immunization against 1999 (EU)
diphtheria, tetanus and pertussis Immunization against 2000 (EU)
hepatitis B
Immunization of 2001 (EU)
children and adolescents against hepatitis B
Vet (active 1996 (EU)
immunization of sows)
Vet. (immunization of 1997 (EU)
cats against various feline pathogens)
Vet. (reduction in 2000 (EU)
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