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biopharmaceuticals biochemistry and biotecnology - Walsh G.

Walsh G. biopharmaceuticals biochemistry and biotecnology - John Wiley & Sons, 2003. - 572 p.
ISBN 0-470-84327-6
Download (direct link): biochemistryandbiotechnology2003.pdf
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Novolog mix 70/30 (contains Novo Nordisk
Insulin Aspart, short-acting rhInsulin analogue, as one ingredient. See also Novomix 30)
Acute myocardial infarction Acute myocardial infarction
Acute myocardial infarction
Acute myocardial infarction Myocardial infarction
Diabetes mellitus
Diabetes mellitus Diabetes mellitus
Diabetes mellitus Diabetes mellitus
Diabetes mellitus Diabetes mellitus
Diabetes mellitus
Diabetes mellitus
1992 (USA)
1999 (EU), 2000 (USA)
1987 (USA) 1996 (EU)
1996 (USA)
1996 (EU) 2001 (EU)
Myocardial infarction 2000 (USA)
1982 (USA)
1991 (USA)
1996 (USA, EU)
1997 (EU) 1997 (EU)
1999 (EU)
2000 (EU)
2001 (USA) 2001 (USA)
APPENDIX 1 501
Product Company Therapeutic indication Date approved
Actrapid/Velosulin/Monotard/ Novo Nordisk Diabetes mellitus 2002 (EU)
Insulatard/Protaphane/Mixtard/
Actraphane/Ultratard (All contain
rhInsulin produced in S. cerevisiae,
formulated as short-intermediate-
long-acting products)
Lantus (Insulin glargine, long- Aventis Diabetes mellitus 2000 (USA, EU)
acting rhInsulin analogue Pharmaceuticals
produced in E. coli)
Optisulin (Insulin glargine, Aventis Diabetes mellitus 2000 (EU)
long-acting rhInsulin Pharmaceuticals
analogue produced in E. coli.
See Lantus)
Protropin (rhGH, differs from Genentech hGH deficiency in 1985 (USA)
human hormone only by children
containing an additional
N-terminal methionine residue.
Produced in E. coli)
Glucagen (rhGlucagon. produced Novo Nordisk Hypoglycaemia 1998 (USA)
in S. cerevisiae)
Thyrogen (Thyrotrophin-a, rhTSH Genzyme Detection/treatment 1998 (USA), 2000
produced in CHO cells) of thyroid cancer (EU)
Humatrope (rhGH, produced in Eli Lilly hGH deficiency in 1987 (USA)
E. coli) children
Nutropin (rhGH, produced in Genentech hGH deficiency in 1994 (USA)
E. coli) children
Nutropin AQ (rhGH, produced Schwartz Pharma Growth failure, 2001 (EU)
in E. coli) AG Turnerís syndrome
BioTropin (rhGH) Biotechnology hGH deficiency in 1995 (USA)
General children
Genotropin (rhGH, produced Pharmacia and hGH deficiency in 1995 (USA)
in E. coli) Upjohn children
Saizen (rhGH) Serono hGH deficiency in 1996 (USA)
Laboratories children
Serostim (rhGH) Serono Treatment of AIDS- 1996 (USA)
Laboratories associated catabolism/
wasting
Norditropin (rhGH) Novo Nordisk Treatment of growth 1995 (USA)
failure in children due
to inadequate growth
hormone secretion
Gonal F (rhFSH, produced Serono Anovulation and 1995 (EU), 1997
in CHO cells) superovulation (USA)
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