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biopharmaceuticals biochemistry and biotecnology - Walsh G.

Walsh G. biopharmaceuticals biochemistry and biotecnology - John Wiley & Sons, 2003. - 572 p.
ISBN 0-470-84327-6
Download (direct link): biochemistryandbiotechnology2003.pdf
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It is now just over a decade since the first nucleic acid-based drugs began initial tests. Several such drugs will likely be in routine medical use in less than one decade more. The application of gene technology could also change utterly the profile of biopharmaceutical drugs currently on the market. Virtually all such products are proteins, currently administered to patients for short or prolonged periods, as appropriate. Gene therapy offers the possibility of equipping the patient’s own body with the ability to synthesize these drugs itself, and over whatever time scale is appropriate. Taken to its logical conclusion, gene therapy thus offers the potential to render obsolete most of the biopharmaceutical products currently on the market. Of all the biopharmaceuticals discussed throughout this text, nucleic acid-based drugs may well turn out to have the most profound influence on the future practice of molecular medicine.
496 BIOPHARMACEUTICALS
FURTHER READING
Books
Blankenstein, T. (Ed.) (1999). Gene Therapy: Principles and Applications. Birkhauser-Verlag.
Crooke, S. (Ed.) (2001). Antisense Drug Technology. Marcel Dekker, New York.
Kresina, T. (Ed.) (2001). An Introduction to Molecular Medicine and Gene Therapy, Parts I and II. Wiley-Liss, New York. Lowrie, D. (1999). DNA Vaccines. Humana, New York.
Phillips, M. (2000). Antisense Technology (Methods in Enzymology, Vol. 313). Academic Press, New York.
Stein, C. & Krieg, A. (1998). Applied Antisense Oligonucleotide Technology. Wiley, Chichester.
Articles
Gene therapy
Buchschacher, G. & Wong-Staal, F. (2001). Approaches to gene therapy for human immunodeficiency virus infection.
Human Gene Ther. 12(9), 1013-1019.
Davies, J. et al. (2001). Gene therapy for cystic fibrosis. J. Gene Med. 3(5), 409-417.
Demeterco, C. & Levine, F. (2001). Gene therapy for diabetes. Frontiers Biosci. 6, D175-D191.
Demoly, P. et al. (1997). Gene therapy strategies for asthma. Gene Therapy 4(6), 507-516.
Docherty, K. (1997). Gene therapy for diabetes mellitus. Clin. Sci. 92(4), 321-330.
Donnelly, J. (1997). DNA vaccines. Ann. Rev. Immunol. 15, 617-648.
Felgner, P. (1997). Nonviral strategies for gene therapy. Sci. Am. June, 86-90.
Ferreira, G. et al. (2000). Downstream processing of plasmid DNA for gene therapy and DNA vaccine applications.
Trends Biotechnol. 18(9), 380-388.
Lewin, A. & Hauswirth, W. (2001). Ribozyme gene therapy: applications for molecular medicine. Trends Mol. Med. 7(5), 221-228.
Liras, A. (2001). Gene therapy for haemophilia: the end of a ‘royal pathology’ in the third millennium? Haemophilia 7(5), 441-445.
Mhashilkar, A. et al. (2001). Gene therapy — therapeutic approaches and implications. Biotechnol. Adv. 19(4), 279-297. Moller, P. & Schadendorf, D. (1997). Somatic gene therapy and its implications in melanoma treatment. Arch. Dermatol. Res. 289(2), 71-77.
Mulligan, R. (1993). The basic science of gene therapy. Science 260, 926-931.
Pfeifer, A. & Verma, I. (2001). Gene therapy: promises and problems. Ann. Rev. Genom. Hum. Genet. 2, 177-211. Phillips, A. (2001). The challenge of gene therapy and DNA delivery. J. Pharm. Pharmacol. 53(9), 1169-1174. Robertson, J. & Griffiths, E. (2001). Assuring the quality, safety and efficacy of DNA vaccines. Mol. Biotechnol. 17(2), 143-149.
Rosenberg, S. (1997). Cancer vaccines based on the identification of genes encoding cancer regression antigens. Immunol. Today 18(4), 175-182.
Schatzlein, A. (2001). Non-viral vectors in cancer gene therapy: principles and progress. Anti-cancer Drugs 12(4), 275-304.
Scott-Taylor, T. & Dalgeish, A. (2000). DNA vaccines. Expert Opin. Invest. Drugs 9(3), 471-480.
Smith, A. (1995). Viral vectors in gene therapy. Ann. Rev. Microbiol. 49, 807-838.
Smith, H. & Klinman, D. (2001). The regulation of DNA vaccines. Curr. Opin. Biotechnol. 12(3), 299-303.
Wu, N. & Ataai, M. (2000). Production of viral vectors for gene therapy applications. Curr. Opin. Biotechnol. 11(2), 205-208.
Antisense technology
Adah, S. et al. (2001). Chemistry and biochemistry of 2'-5' oligoadenylate-based antisense strategy. Cur. Med. Chem. 8(10), 1189-1212.
Akhtar, S. et al. (2000). The delivery of antisense therapeutics. Adv. Drug Delivery Rev. 44(1), 3-21.
Askari, F. (1996). Molecular medicine: antisense-oligonucleotide therapy. N. Engl. J. Med. 334(5), 316-318.
Galderisi, U. et al. (2001). Antisense oligonucleotides as drugs for HIV treatment. Expert Opin. Therapeut. Patents 11(10), 1605-1611.
Hughes, M. et al. (2001). The cellular delivery of antisense oligonucleotides and ribozymes. Drug Discovery Today 6(6), 303-315.
Lebedeva, I. & Stein, C. (2001). Antisense oligonucleotides: promise and reality. Ann. Rev. Pharmacol. Toxicol. 41, 403-419.
Pawlak, W. et al. (2000). Antisense therapy in cancer. Cancer Treatment Rev. 26(5), 333-350.
NUCLEIC ACID THERAPEUTICS 497
Reddy, D. (1996). Antisense oligonucleotides: a new class of potential anti-AIDS and anti-cancer drugs. Drugs Today 32(2), 113-137.
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