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The constituents of medicinal plants - Pengelly A.

Pengelly A. The constituents of medicinal plants - London, 2001. - 109 p.
Download (direct link): theconstituents2001.djvu
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Urtica dioica - stinging netde root. Recent experiments demonstrate a potent inhibition of enzymes involved in benign prostatic hyperplasia. Steroidal compounds including stigmast-4-en-3-one are thought to be responsible for this activity [Hirano et al 1994].
Commiphora mukul- myrrh (known as guggal in India). The resin contains steroids known as guggulsterones which lower blood cholesterol and triglycerides via stimulation of thyroid function (Bruneton 1995].
SAPONINS
Saponins are naturally occurring glycosides whose active portions are soluble in water, and which produces a lather. The combination of lipophilic aglycones (or sapogenins) with water-soluble sugars gives them the ability to lower surface tension, producing the characteristic detergent or soap-like effect on membranes and skin (Harborne & Baxter 1993]. Classification of saponins is based on the chemical structure of their aglycones, referred to as sapogenins.
THterpenoid saponins
The most widely distributed aglycone is oleanolic acid -hence the “oleanolic acid ring system". Other aglycones have their own characteristic structures, eg. the ursane and dammarane ring systems. This group is pentacyclic ie. contains five carbon rings.
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Steroidal saponins
These saponins contain steroid structures as their aglycones. They possess C27 skeletons in structures which are generally arranged into six rings. Some are used as precusors of sex hormones, cortisone, vitamin D. Examples are diosgenin and hecogenin.
Glycoalkaloids
A sub-group of the steroidal saponins are the glycoalkaloids, in which the aglycone is a steroidal alkaloid (contains an N atom). These are commonly found in the Solarium genus.
THERAPEUTIC ACTION OF SAPONINS
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Local effect
The detergent effect referred to above is important in understanding the significant local effects of saponins. Many good wound healing herbs are rich in saponins, including Calendula officinalis and Arnica montana (both Asteraceae). Irritant effect on mucous membranes of respiratory and urinary tracts is responsible for the expectorant and diuretic properties of saponin rich herbs such as Polygala senega (Polygonaceae) and Primula spp. (Primulaceae).
Their local effect is also observed in the digestive system where they increase and accelerate the bodies ability to absorb some active components eg. calcium and silica from foods. They generally assist digestion (though can become emetics in large quantities) and are found in many foods including tomatoes, spinach, asparagus, soya beans and oats.
Systemic effect
The aglycones once absorbed have favourable effects on blood vessel walls. Saponins from the horse chesnut -Aesculus hippocastanum (Hippocastanaceae) and butchers
broom - Ruscus aculeatus (Liliaceae) are beneficial for varicose veins and haemorrhoids, while those from lime flowers - spp.(Tiliaceae) assist by lowering blood cholesterol.
Haemolytic effect
Saponin aglycones are capable of increasing permeability of membranes. They can cause haemolysis by destroying the membranes of red blood cells, thus releasing the haemoglobin.
Taken orally the detergent effect is nullified in the stomach before aglycones are absorbed into the bloodstream eg. Phytolacca decandra (Phytolaccaceae). Haemolysis can also occur by absorbtion through skin - cuts, eyes etc. A recent study revealed haemolytic rates in steroidal saponins were fast compared to those of triterpenoids. [Takechi & Tanaka 1995].
Other actions of saponins Anti-inflammatory - glycyrhizzin from liquorice Antifungal, antimicrobial
Hepatoprotective - saikosaponins from Bupleurum spp.
(Apiaceae), ginsenosides from Panax spp. (Araliaceae). Molluscicidal
The chemical composition of some saponins is very similar to that of human hormones.
Their aglycones have similar chemical structure to steroid hormones ie. stress & sex hormones from adrenals and gonads. They form the chemical basis for the herbal adaptagens.
Herbal adaptagens
These agents are referred to as ‘harmony remedies’ by Stephen Fulder in his excellent book originally titled “The Root of Being. Ginseng and the Pharmacology of Harmony’’ [Fulder 1980], still one of the best analyses of this class of medicinal agent. The concept of adaptagens is based
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around enhancement of vitality and general resistance rather than treatment of specific illnesses.
“ By helping the body cope with stress, adaptogens can help accelerate learning speed, improve the memory, increase stamina in high performance athletes, alleviate small complaints and cut down infections by acting as a prophylactic” [Wahlstrom 1987].
Other compounds besides saponins may also be implicated in adaptagenic activity, particularly polysaccharides such as those found in some well known medicinal mushrooms.
Examples of adaptagenic herbs
Panax ginseng and Pan ax spp., Eleulhrococcus, Glycyrhizza, Smilaxspp., Dioscorea spp., Centella asiatica, Bupleurum spp., and Gandoderma- the reishi mushroom.
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