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Organic Synteses vol 70 - Meyers A.I.

Meyers A.I. , Boecman R.K. Organic Synteses vol 70 - John Wiley & Sons, 1992. - 163 p.
ISBN 0-471-57743
Download (direct link): organicsynthesesvol701992.pdf
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6. A clean dropping funnel should be used for the addition of the methyllithium solution, and should be filled with rigorous exclusion of air. It is simpler to employ a syringe pump, and replace the dropping funnel with a septum. In this case the stream of nitrogen can be introduced by a needle through the septum.
All toxic materials were disposed of in accordance with "Prudent Practices for Disposal of Chemicals from Laboratories"; National Academy Press; Washington, DC, 1983.
Tris(trimethylsilyl)silane 1 can be substituted for toxic stannanes like tributyl-stannane 2 in organic syntheses which involve radicals,2 because: a) silyl radicals are as efficient as stannyl radicals in the radical-forming step,3 and b) the Si-H bond strength in tris(trimethylsilyl)silane 1 is only slightly higher than the Sn-H bond strength in tributylstannane 2.4
Bond energy (kcal/mol):
Waste Disposal Information
3. Discussion
79
74
(Me3Si)3Si H
1
Bu3Sn - H
2
166
Thus, heating a mixture of an organic bromide or iodide with equimolar amounts of silane 1 and catalytic amounts of a radical initiator like azobisisobutyronitrile gives organic radicals 3 that can undergo addition, cyclization or rearrangement reactions2 (3 -> 4) before hydrogen abstraction5 yields the product.
Tris(trimethylsilyl)silane 1 is a mediator in this reaction. In contrast to the reported method,6 the synthesis described in this procedure gives silane 1 in high yields in a one-pot reaction.
1. Institute of Organic Chemistry, University of Basel, St. Johanns-Ring 19, CH-4056 Basel, Switzerland.
2. Giese, B.; Kopping, B.; Chatgilialoglu, C. Tetrahedron Lett. 1989, 30, 681; Kulicke, K. J.; Giese, B. Synlett. 1990, 91.
3. Ballestri, M.; Chatgilialoglu, C.; Clark, K. B.; Griller, D.; Giese, B.; Kopping, B. J. Org. Chem. 1991, 56, 678.
4. Kanabus-Kaminska, J. M.; Hawari, J. A.; Griller, D.; Chatgilialoglu, C. J. Am. Chem. Soc. 1987, 109, 5267.
5. Chatgilialoglu, C.; Griller, D.; Lesage, M. J. Org. Chem. 1988, 53, 3641.
6. Gilman, H.; Smith, C. L. J. Organometat. Chem. 1968, 14, 91; Gutekunst, G.; Brook, A. G. J. Organometat. Chem. 1982, 225, 1; Bürger, H.; Kilian, W. J. Organomet. Chem. 1969, 18, 299.
(Me3Si)3Si •
(Me3Si)3SiH 4 - (Me3Si)3Si ■
R-Hal
R-
3
R'-H
167
Appendix
Chemical Abstracts Nomenclature (Collective Index Number); (Registry Number)
Tris(trimethylsilyl)silane: Trisilane, 1,1,1,3,3,3-hexamethyl-2-(trimethylsilyl)-(8,9); (1873-77-4)
Chlorotrimethylsilane: Silane, chlorotrimethyl- (8,9); (75-77-4) Tetrachlorosiiane: Silicon chloride (8); Silane, tetrachloro- (9); (10026-04-7) Methyllithium-lithium bromide complex: Lithium, methyl- (8,9); (917-54-4)
168
9-BORABICYCLO[3.3.1]NONANE DIMER (9-Borabicyclo[3.3.1]nonane, dimer)
O
BHa-SMe?
(CH2OMe)2
Submitted by John A. Soderquist1 and Alvin Negron. Checked by Daniel M. Berger and Larry E. Overman.
1. Procedure
Caution! The manipulation and handling of air-sensitive compounds requires the use of special techniques. While no difficulties have been encountered with the present procedures, the preparer should consult References 2 and 3 prior to carrying out these syntheses.
A 2-L, three-necked, round-bottomed flask containing a magnetic stirring bar is fitted with a 250-mL addition funnel and a distillation assembly set for downward distillation to a 500-mL receiver flask. Rubber septa are used to isolate the system from atmospheric contact. Under a nitrogen purge, vented to an exhaust hood through a mercury bubbler, the entire system is thoroughly flame-dried (Note 1). After the 2-L flask is cooled to room temperature, it is charged with 500 mL of pure, dry 1,2-dimethoxyethane (Note 2) and 153 mL (1.53 mol) of borane-methyl sulfide complex (Note 3) employing a double-ended needle to effect the transfer. With a similar technique, 164 g (1.52 mol) of 1,5-cyclooctadiene (Note 4) is transferred to the addition funnel. To the stirred borane solution, 1,5-cyclooctadiene is added dropwise over ca. 1 hr to maintain a reaction temperature of 50-60°C during which time a small
169
amount of dimethyl sulfide (bp 38°C) distills slowly from the reaction mixture. After the addition is completed, the addition funnel is replaced with a glass stopper and approximately 300 mL of the solution is distilled to reach a final distillation temperature of 85°C, indicating the complete removal of dimethyl sulfide from the reaction mixture (Note 5). If the distillate temperature does not reach 85°C, 150 mL of additional 1,2-dimethoxyethane is added and the distillation is continued until the distillate temperature reaches 85°C. The distillation assembly is replaced with a rubber septum and 1,2-dimethoxyethane is added to the reaction flask to bring the total liquid volume to 1 L. The mixture is warmed to effect the dissolution of the solid and allowed to cool very slowly to 0°C, which results in the formation of crystalline 9-borabicyclo[3.3.1]nonane (9-BBN) dimer. The supernatant liquid is decanted from the product using a double-ended needle and the 9-BBN dimer is dissolved in 1 L of fresh 1,2-dimethoxyethane. After the flask is cooled to 0°C, the supernatant liquid is removed as above and the large needles are dried under reduced pressure for 12 hr at 0.1 mm to give 158-165 g (85-89%) of product (mp 152-154°C, sealed capillary) (Notes 6-8).
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