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Organic Synteses vol 70 - Meyers A.I.

Meyers A.I. , Boecman R.K. Organic Synteses vol 70 - John Wiley & Sons, 1992. - 163 p.
ISBN 0-471-57743
Download (direct link): organicsynthesesvol701992.pdf
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5. A disadvantage of the present procedure is that it requires the use of the relatively foul-smelling substance, ethyl isocyanoacetate. Although this material is commercially available (from, e.g., Aldrich Chemical Company, Inc.), it is moderately expensive. The authors have found that the existing preparative procedure (Hartman,
G. D.; Weinstock, L. M. Org. Synth., Coll. Vol V11988, 620) can be improved by the use of trichloromethyl chloroformate (Kurita, K.; Iwakura, Y. Org. Synth., Coll. Vol. VI 1988, 715) rather than phosphoryl chloride. This substitution simplifies purification of the isocyanoacetate by eliminating the aqueous portion of the workup.
6. DBU was obtained from Aldrich Chemical Company, Inc. and used as received.
7. Two equivalents of DBU are used here. One equivalent of DBU eliminates acetate from one of the reactants to form 3-nitro-3-hexene in situ, which goes on to form the pyrrole. The intermediate ethyl 3,4-diethylpyrrole-2-carboxylate can also be
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prepared directly from ethyl isocyanoacetate and 3-nitro-3-hexene in good yield (86%) under conditions similar to those outlined here.5 Although this alternative requires a further manipulative step, it requires only half as much DBU.
8. It is important not to allow the temperature to drop below 20°C because the reaction slows down considerably. Unreacted DBU then builds up. As a result, when the temperature does climb, it does so rapidly (often to as high as 65°C). This results in a significantly lower yield.
9. The spectral and physical properties are as follows: 1H NMR (CDCI3, 300 MHz) 5: 1.16 (t, 6 H, CH2CH3), 2.47 (q, 4 H, CH2CH3), 6.42 (d, 2 H, pyrrole CH), 7.65 (s, 1 H, pyrrole NH); MS m/e (relative intensity) 123 (46), 108 (100), 93 (37); bp 100°C/25 mm; 69°C/7 mm (lit.6 bp, 83°C/10 mm).
10. Benzene is a known carcinogen. Follow manufacturer's recommended procedures for handling, storage, and disposal.
11. Chloroform is a suspected carcinogen. Follow manufacturer's recommended procedures for handling, storage, and disposal.
12. The spectral and analytical properties are as follows: 1H NMR (CDCI3, 300 MHz) 5: -3.72 (s, 2 H, NH), 1.95 (t, 24 H, CH2CH3). 4.12 (q, 16 H, CH2CH3), 10.12 (s, 4
H, meso CH); HRMS, M+ 534.37351 (calcd for C36H46N4: 534.37225). Anal. Calcd for C36H46N4: C, 80.85; H, 8.67; N, 10.48. Found: C, 80.89; H, 8.56; N, 10.37; UV-vis (СНСІз-МеОН 95:5 vv.) X.max (log є): 398 (5.20), 498 (4.10), 533 (4.00), 565 (3.79), 618 (3.68) nm.
Waste Disposal Information
All toxic materials were disposed of in accordance with "Prudent Practices for Disposal of Chemicals from Laboratories"; National Academy Press; Washington, DC, 1983.
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3. Discussion
Octaethylporphyrin (OEP) and tetraphenylporphyrin (TPP) remain among the most widely used of an increasingly diverse set of available synthetic porphyrins. The inherently high symmetry and relatively good solubility properties of these systems often combine to make them the models of choice for a wide range of biological modeling and inorganic chemical applications.7 Recently, an optimized synthesis of TPP and related tetraarylporphyrins has been developed by Lindsey and co-workers.8 At present, however, the synthesis of OEP (5) remains problematic: Although numerous strategies have been reported,5,9-14,15 no convenient, high-yield procedure currently exists.
Traditionally, octaethylporphyrin has been prepared by the self-condensation of
2-N,N'-diethylaminomethyl-3,4-diethylpyrrole,9-10 ethyl 5-N,N'-diethylaminomethyl-
3.4-diethylpyrrole-2-carboxylate,11-12 or 3,4-diethyl-5-hydroxymethylpyrrole-2-carboxylic acid under oxidative conditions.13 It has also been prepared on a small scale directly from 3,4-diethylpyrrole in 65% yield by condensation with aqueous formaldehyde under acid-catalyzed conditions,14 using conditions similar to those which have proved useful for preparing the corresponding octamethylporphyrin analogue.16 All of these syntheses derive from the same, initial pyrrole precursor, namely, ethyl 3,4-diethyl-5-methylpyrrole-2-carboxylate, prepared from the classic, reverse-sense Knorr reaction of ethyl propionylacetate with 2,4-pentanedione, and they require several steps before the ultimate porphyrin-forming condensation. Octaethylporphyrin has also been prepared recently by the reduction of 2,8,12,18-tetraacetyl-3,7,13,17-tetraethylporphyrin by diborane,14 and by the condensation of
3.4-diethylpyrrole-N-carboxylic acid with formaldehyde in refluxing acetic acid/pyridine.15 Neither of these procedures, however, truly overcomes the problem associated with preparing the initial pyrrole.
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The synthesis reported here circumvents many ol the problems associated with existing preparative methods. Specifically, it makes use of a new procedure of Barton and Zard4 in the key pyrrole-forming step. This method, which gives an a-unsubstituted pyrrole ester (e.g., 3) directly in good yield, provides a substantial saving in labor when compared to the Knorr approach, and it is very flexible with regard to the kinds of p-substitution allowed. Since the remaining a-ester group can be conveniently removed by saponification and subsequent decarboxylation (often, as is the case here, without isolation of the initial pyrrole product), this method provides a quick and easy means of preparing 3,4-dialkylated pyrroles. Simple acid-catalyzed condensation of the resulting 3,4-dialkylpyrroles with formaldehyde and subsequent oxidation is then all that is required to complete the synthesis of an octaalkylporphyrin.17'18 We have found that these latter transformations may be readily effected using aqueous formaldehyde under acid-catalyzed dehydrating conditions, followed by simple air-induced oxidation, in the specific case of octaethylporphyrin, when the reaction is run on a 1-g scale, a 75% yield of analytically pure product is obtained following workup and purification (which involves only simple recrystallizations and no chromatographic separations). This procedure can be conveniently scaled up by a factor of ten. Under these conditions, it still gives a good yield (55%) of pure product. It does, however, require relatively large amounts of benzene (3 L for a reaction carried out with 10 g of 3,4-diethylpyrrole), which could present a health hazard. However, if due caution is exercised with regard to this point, the present method provides an easy way to prepare large quantities of octaethylporphyrin. As such it represents a considerable advance over earlier methods in terms of both ease and convenience.
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