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The porphyrin handbook - Kadish K.M.

Kadish K.M. The porphyrin handbook - Academic press, 2000. - 368 p.
Download (direct link): kadishsmishgulilard2000.djvu
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Porphyrins as Photosensitizers in 43 Photodynamic Therapy
RAVINDRA K. PANDEY3 b and GANG ZHENG3
a Photodynamic Therapy Center, Roswell Park Cancer Institute, Buffalo,
New York 14263-001 USA bDepartment of Nuclear Medicine, Roswell Park
Cancer Institute, Buffalo, New York 14263-001 USA
I.
Introduction.............................................................
.................................... 158
A. A Brief History of Photodynamic
Therapy..................................................................
. 158
B. Mechanisms of Tumor
Necrosis.................................................................
............. 159
1.
Hydrophobicity...........................................................
............................... 160
2.
pH.......................................................................
............................... 160
3. Lymphatic
Clearance................................................................
..................... 160
4. Serum Protein
Binding..................................................................
................. 160
C. Basic Requirements for an Ideal Photosensitizer for
PDT................................................... 160
D. Advantages and Limitations of
Photofrin................................................................
... 161
II. Porphyrin-Based
Photosensitizers.........................................................
.................... 161
A. Theoretical
Considerations...........................................................
..................... 161
B. Hematoporphyrin and Protoporphyrin
Analogues..............................................................
162
C. Tetraphenylporphyrin (TPP)
Analogues................................................................
...... 163
III. Chlorin-Based
Photosensitizers.........................................................
...................... 164
A. Modification of Chlorophyll
a........................................................................
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