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Solid-phase organik syntheses - Burdges K.

Burdges K. Solid-phase organik syntheses - John Wiley & Sons, 2000. - 283 p.
ISBN 0-471-22824-9
Download (direct link): phaseorganicsynthesis2000.pdf
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H.-S.; Schore, N. E.; Kurth, M. J. A Polymer-Supported C2-Symmetric Chiral Auxiliary: Preparation of Non-Racemic 3,5-Disubstituted-y-Butyro-
244 VIBRATIONAL SPECTROSCOPY
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REFERENCES 245
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1999, in press.
Solid-Phase Organic Synthesis. Edited by Kevin Burgess Copyright 2000 John Wiley & Sons, Inc. ISBNs: 0-471-31825-6 (Hardback); 0-471-22824-9 (Electronic)
CHAPTER 8
RECENT ADVANCES IN SOLID-PHASE SYNTHESIS OF NATURAL PRODUCTS
x x ^ natural products and
intermediate ---------------------> . , M , .
Up natural product analogs
LAWRENCE J. WILSON Procter & Gamble Pharmaceuticals
8.1. INTRODUCTION
Solid-phase synthetic methods1,2 feature convenient purification procedures coupled with opportunities for automation.3-5 These attributes have been widely exploited to prepare libraries of small molecules via parallel and combinatorial approaches. A logical extrapolation of these efforts is the supported syntheses of larger, more complex natural products and natural product analogs. Such efforts are consistent with the pharmaceutical industry objectives behind most high-throughput syntheses since, historically, the unique properties of natural products have provided a fertile ground for
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