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Solid-phase organik syntheses - Burdges K.

Burdges K. Solid-phase organik syntheses - John Wiley & Sons, 2000. - 283 p.
ISBN 0-471-22824-9
Download (direct link): phaseorganicsynthesis2000.pdf
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I. Preparation of the Solid Support. Poly[P-(Propen-3-01-l-Yl)Styrene], J. Am. Chem. Soc. 1971,93,492. (b) Crowley, J. I.; Rapoport, H. Unidirectional Dieckmann Cyclizations on a Solid Phase and in Solution, J. Org. Chem. 1980,45,3215. (c) Blanton, J. R.; Salley, J. M. Reducing Alkyl Halides Using a Polymer-Bound Crown Ether/Tin Hydride Cocatalyst, J. Org. Chem. 1991, 56,490. (d) Kurth, M. J.; Randall, L. A. A.; Chen, C.; Melander, C.; Miller, R. B.; McAlister, K.; Reitz, G.; Kang, R.; Nakatsu, .; Green, C. Library-Based Lead Compound Discovery: Antioxidants by an Analogous Synthe-sis\Deconvolutive Assay Strategy, J. Org. Chem. 1994, 59, 5862. (e) Moon,
H.-S.; Schore, N. E.; Kurth, M. J. A Polymer-Supported C2-Symmetric Chiral Auxiliary: Preparation of Non-Racemic 3,5-Disubstituted-y-Butyro-
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1996,38,6851. (i) Deben, I. E. A.; van Wijk, . H. .; van Doornum, E. .; Hermkens, P. H. H.; Kellenbach, E. R. Characterization of Reaction Products on Solid Supports by FT-IR, Mikrochim. Acta (Suppl.) 1997,14, 245.
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8. Gremlich, H.-U.; Berets, S. L. Use of FT-IR Internal Reflection Spectroscopy in Combinatorial Chemistry, Appl. Spectr. 1996, 50, 532.
9. Yan, B; Li, W. Rapid Fluorescence Determination of the Absolute Amount of Aldehyde and Ketone Groups on Resin Supports, J. Org. Chem. 1997, 62, 9354.
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1999, in press.
Solid-Phase Organic Synthesis. Edited by Kevin Burgess Copyright 2000 John Wiley & Sons, Inc. ISBNs: 0-471-31825-6 (Hardback); 0-471-22824-9 (Electronic)
x x ^ natural products and
intermediate ---------------------> . , M , .
Up natural product analogs
LAWRENCE J. WILSON Procter & Gamble Pharmaceuticals
Solid-phase synthetic methods1,2 feature convenient purification procedures coupled with opportunities for automation.3-5 These attributes have been widely exploited to prepare libraries of small molecules via parallel and combinatorial approaches. A logical extrapolation of these efforts is the supported syntheses of larger, more complex natural products and natural product analogs. Such efforts are consistent with the pharmaceutical industry objectives behind most high-throughput syntheses since, historically, the unique properties of natural products have provided a fertile ground for
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