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Bioinformatics. A Practical Guide to the Analysis of Genes and Proteins - Baxevanis A.D.

Baxevanis A.D. Bioinformatics. A Practical Guide to the Analysis of Genes and Proteins - New York, 2001. - 493 p.
ISBN 0-471-22392-1
Download (direct link): bioinformaticsapractic2001.pdf
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2. How large is this region in cM?
3. What polymorphic markers can be identified in this region (that you might use to try to narrow the region)? Choose six of these polymorphic markers. Based on the chosen markers, can a map based on these markers be identified or constructed?
4. What STS markers have been developed for SOD1? What are their map positions on the Human Transcript Map (GeneMap ’99)? Are these positions statistically well-supported? Have any SNP markers been identified within SOD1?
5. What other genes are in this region?
6. Has the region including the SOD1 gene been sequenced? What contigs and/or clones contain SOD1?
7. Have orthologous regions been identified in any other species?
8. Have mutations in SOD1 been associated with any diseases other than Bioinformatosis?
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